Course name: Basic Genetics

Course BT-106                              Full Marks: 100                                          Unit 1                   Credit 3.5   

1. Mendel’s Law of Inheritance:

Mendelian principles, experiments and achievements, monohybrid and dihybrid inheritance, mendelian genetics in humans.

2. Deviation of Mendel’s Law of Inheritance:

a).  i). Dominant (12:3:1) and recessive (9:3:4) epistasis, ii). Duplicate dominant (9:7) and duplicate recessive(15:1) genes,  iii) dominant and recessive interaction (13:3), iv). Duplicate gene with cumulative effect (9:6:1), b). Pleiotropism and phenocopy.

3. Multiple allele and pseudoallele:

Definition, characteristics, example and importance.

4. Linkage and Recombination:

Discovery of linkage: autosomal & sex, linkage map, two and three point  test cross for linkage detection, genetic interference and coincidence.

5. Sex determination:

a). Mechanism of  sex determination in man, grasshopper, Drosophila and fowl, Balance theory of sex determination. b). Sex linked inheritance, Sex influence and sex limited characters.

6. Cytoplasmic inheritance:

a). Variegation in leaves of higher plants. b). Inheritance of extranuclear genes. c). Maternal inheritance.

7. Chromosomal  abnormalities :

Variation in the number and structure of chromosomes: Haploids, Missing or extra-chromosomes ( Euploids, Aneuploids), Deletion, Duplication, Abberations, Translocation and other structural rearrangements. Chromosomal studies- Fish, Karyotyping.

8.Gene linkage and Choromosome mapping:

Genetic linkage and gene mapping, detection and estimation of genetic linkage in humans, genetic mapping of human chromosome.

9. Human Genetics:

Pedigree analysis, Aminocentesis,  Twins, Human traits, disorders due to mutant genes.

Books Recommended:

1.  Monooe W. Strikberger: Genetics.

2. Adrian M. SRB: General Genetics.

3. Enmund W. Sinnott: Principle of Genetics.

4. Gupta: Genetics.